General Instructions

In this activity, you will be given a series of questions. These questions will involve identifying molecular relationships, explaining Fischer projections, and identifying isomers from a given structure. The link to a chemistry drawing tool is provided; you should explore the features and familiarize yourself with the functions before starting the activity. Note that you are not required to share the structures or mechanisms you drew when sharing your responses.

Step 1 - Review

Review the material from this module, paying particular attention to chirality, stereogenicity, and Fischer projections.

Step 2 - Respond

Answer the following questions:

1. Determine the relationship for each pair of molecules (enantiomers, identical, constitutional isomers, non-isomer) and provide brief explanations of the reasoning behind your answers.

1. 
   
   

2. 
   
   

2. When drawing Fischer Projections, if the lowest priority group is on a horizontal bond (as in the following structure), we determine the priority decrease direction, then reverse the answer to the opposite way to get the final configuration. In your own words, explain why this procedure is followed.
   

3. Use the chemistry tool to draw the structures of all the stereoisomers for 1-bromo-2-chlorocyclobutane. Then, describe your approach and indicate the relationship between the stereoisomers.
   

Step 3: Share 

To share your work, click the “Add a new discussion topic” button under this post and paste your work into the “Message” box. Make sure to reference others’ intellectual property when necessary. All references should follow 7th Edition APA formatting. For further instructions, see the resource on the Himmelfarb Health Sciences Library: APA citation resource (N.B.: references are excluded from word counts). You do not need to share your drawings in the Chemistry tool, but you can discuss them if required.

Step 4: Interact 

To complete the activity, evaluate and categorize the work from one of your peers based on items A - E of the rubric below. Provide a rationale for your grade and comments or suggestions for improvement. To post a reply, click “Reply” on a particular discussion, write your feedback and click “Post to forum.” You can use the list below as an example:

Item A is  .…. because….  My suggestions for improvement are….
Item B is  .…. because….  My suggestions for improvement are….
Item C is  .…. because….  My suggestions for improvement are….
Item D is  .…. because….  My suggestions for improvement are….
Item E is  .…. because….  My suggestions for improvement are….

OPTIONAL Step 5: Interact (10 minutes)

If you would like to, you can reply to your peers' posts in a respectful and professional manner. Ensure that your post engages your peers' ideas by including a reflection on their comments, sharing ideas of other potential difficulties and parties involved, or asking thought-provoking questions. If a peer comments on your posting, please reply. To post a reply, click “Reply” on a particular discussion, write your feedback and then click on “Post to forum.”