Section: Module 4: Lesson 9: Gestational Trophoblastic Neoplasia (GTN) | Obstetrics and Gynecologic Clerkship for Medical Students | NextGenU.org

  • Student Learning Outcomes:
    Upon completion of this module, students you will be able to:
    • Describe the symptoms and physical examination findings of a patient with GTN, including molar pregnancy.
    • Describe the diagnostic methods, treatment options and follow-up for GTN, including molar pregnancy, with consideration of value-based care and the social and environmental factors that may influence health outcomes.
    • Recognize the difference between molar pregnancy and malignant GTN, and the importance of making a correct diagnosis and initiating therapy quickly.
    Approximate time required for the readings for this lesson (at 144 words/minute): 3 hours and 18 minutes.

    • Required Learning Resources and Activities
    • Watch the entire video. (6 minutes)

      APGO - 2016

    • Watch the entire video. (10 minutes)

      APGO - 2019

    • Read the entire content. (30 minutes)

      NHI - 2019

    • Read the entire content. (28 minutes)

      NHI - 2018

    • Introduction: 

      The management of unusual pregnancies, such as molar pregnancies, is an important aspect of gynecological practice. This case study aims to enhance the student's understanding of the diagnosis, management, and complications of molar pregnancies. This case emphasizes the diagnostic process for unusual pregnancies, such as molar pregnancies, and the importance of proper management, including post-treatment monitoring and patient counseling. It also highlights potential complications and their management.

      Case Profile: 

      A 16-year-old primigravida arrives for routine prenatal care. She's 15 weeks pregnant, according to her last menstrual period. She's been experiencing mild nausea but otherwise feels healthy. Her pregnancy has been unremarkable so far. She receives support from her parents and the baby's father.

      A physical examination shows an enlarged uterus, measuring about 22 cm from the pubic symphysis. Fetal heart tones are not detectable by Doppler. She denies any vaginal bleeding or passage of tissue. The vaginal examination is unremarkable.

      Routine prenatal labs are unremarkable except for slightly elevated beta hCG levels at 120,000 mIU/ml and slightly low TSH, indicating mild hyperthyroidism. An ultrasound shows an enlarged uterus with multiple internal echoes and a "snowstorm" appearance. No fetus is visible. The ultrasound also reveals enlarged cystic ovaries bilaterally.

      Activity Questions:

      • What is the differential diagnosis prior to receiving the ultrasound result? 
        Hint: Consider the possible causes of an enlarged uterus and high hCG levels.

      • What aspects of the ultrasound guide the diagnosis? 
        Hint: Focus on the specific ultrasound findings typical of molar pregnancy and the significance of the ovarian cysts.

      • What further evaluations are necessary for a definitive diagnosis? 
        Hint: Consider the tests needed to confirm the diagnosis and determine the presence of metastatic disease.

      • What is the epidemiology and clinical course of this condition? 
        Hint: Discuss the prevalence, risk factors, and potential complications of molar pregnancy.

      • What is your management plan? 
        Hint: Discuss the steps for managing a molar pregnancy, from initial treatment to follow-up.

      Share: 

      To share your work, click the "Add a new discussion topic" button under this post and paste your work into the "Message" box. Remember to reference others' intellectual property when necessary. All references should follow the 7th Edition APA formatting. For further instructions, see the resource on the Himmelfarb Health Sciences Library: APA citation resource (Note: references are excluded from word counts).

      Interact: 

      To complete the activity, you must reply to at least two posts made by your peers in a respectful and professional manner. Make sure your post engages your peers' ideas by including a reflection on their comments, sharing ideas about other potential difficulties and involved parties, or asking thought-provoking questions. If a peer comments on your post, please reply. To post a reply, click "Reply" on a particular discussion, write your feedback, and then click "Post to forum."